DESIGN AND SYNTHESIS OF LACTAMS DERIVED FROM MUCOCHLORIC AND MUCOBROMIC ACIDS AS PSEUDOMONAS AERUGINOSA QUORUM SENSING INHIBITORS

Design and Synthesis of Lactams Derived from Mucochloric and Mucobromic Acids as Pseudomonas aeruginosa Quorum Sensing Inhibitors

Bacterial infections, particularly hospital-acquired infections caused by Pseudomonas aeruginosa, have become a global threat with a high mortality rate.Gram-negative bacteria including P.aeruginosa employ N-acyl homoserine lactones (AHLs) as chemical signals to regulate the expression of pathogenic phenotypes through a mechanism called quorum sens

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Impact of broad categorization on statistical results: How underrepresented minority designation can mask the struggles of both Asian American and African American students

Although recent research has reported equity gains in the university-level physics classroom, there remains evidence of significant inequities by race.We conducted a series of multiple linear regressions to examine the magnitude of these inequities in introductory mechanics final exam scores.When we followed a common method of grouping students by

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MSC-derived exosomes deliver ZBTB4 to mediate transcriptional repression of ITIH3 in astrocytes in spinal cord injury

Background: BMSC-secreted exosomes (BMSC-Exos) have shown potential for promoting behavioral recovery following spinal cord injury (SCI).However, its role in blocking astrocyte activation remains unclear.Thus, this study aimed to determine whether BMSC-Exos impair the function of astrocytes following SCI in mice and to seek the mechanism.Methods: B

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